What Is Nitrosigine® and How Can I Benefit From It?

One of Performance Inspired’s most popular products is our Explosive Pre-Workout formula. It’s an easy-to-mix powder that you can simply add to your water approximately thirty minutes before a workout to give you extra stamina, energy, and focus. Our site explains that this formula “is made with Nitrosigine®—a patented complex of bonded arginine and silicon plus citrulline, beta-alanine, grape seed, green tea extract, and creatine.”

That sounds great, right? It is! But since we get lots of messages asking us what Nitrosigine® is, we want to explain it and what its benefits are. Once you understand its benefits, you will see why we use it.

Nitrosigine® is the brand name for inositol-stabilized arginine silicate. Let’s break this down.

Arginine, which is also known as L-arginine, is an amino acid that assists in many different bodily functions, including:

• Wound healing
• Helping the kidneys remove waste products from the body
• Maintaining immune and hormone function
• Dilates and relaxes the arteries

An article in the journal Nutrients explains that “silicon is a trace element, found in plant foods, thought to increase the bioavailability of L-arginine, and plays an essential role in the body (e.g., skin, hair, immune function)” and that “potentially helps to maintain vascular integrity in vascular diseases that occur with age.”

Inositol is a sugar found in our bodies and that is necessary for the growth and development of cells.

Nitrosigine® is a combination of these and is proven to have great benefits, especially for those who work out regularly. So let’s look at some of these benefits.

1. Nitrosigine® increases vasodilation (the widening of blood vessels)

Nitrosigine® increases the levels of arginine in your blood. This converts into nitric oxide, which acts as a vasodilator, thus improving circulation. This improved circulation allows more oxygen and nutrients to flow to the muscles. During a workout, this helps increase your energy levels. But this increased energy effect doesn’t just last while you work out; the benefits remain for several hours. An article in Men’s Journal reports that “Nitrosigine® elevated blood arginine levels for up to six hours, which means a greater NO [nitric oxide] release long after your training session is over. It was even shown to increase energy levels both immediately and over time.”

This function is especially critical when you perform resistance or endurance training, as it helps the nutrients and oxygen go directly to the muscle group that you are working. This enhanced blood flow also helps with muscle recovery.

2. Nitrosigine® boosts muscle pump

Men’s Health explains that muscle “pump occurs when contractions prevent your veins from taking blood out of the muscles you’re working. Meanwhile, blood continues to be forced in. As it collects, excess plasma causes muscle fibers to stretch. . . . Your muscles interpret this as a threat to their integrity and channel their efforts into reinforcing the cells, resulting in greater mass and strength gain.”

This in turn helps you increase your muscle volume, which is often the end goal of a workout.

3. Nitrosigine® may help reduce muscle damage

Research has found that Nitrosigine® can significantly reduce the markers of muscle damage from exercise, including creatine kinase, which is an enzyme found in the muscles and brain. One study showed that Nitrosigine® reduced these creatine kinase levels after exercise by nearly 56%.

4. Nitrosigine® may offer cognitive benefits

A 2021 study published in Nutrients supports the claim that Nitrosigine® helps improve cognitive function. It states that they found “improved global cognition and immediate memory performance” and that it “significantly improved immediate memory scores by 27%.” This is an added benefit to those who are using it mainly for increased muscle mass and strength.

5. Nitrosigine® may help with decreasing feelings of fatigue

One study found that those who took Nitrosigine® experienced a decrease in perceived fatigue after workouts. This is great news, especially for those who work out in the mornings or afternoons and must function at work the rest of the day. Plus, it adds to the positive psychological effects of the workout when you know that you will not feel as exhausted or achy afterward.

All of these reasons are why we add Nitrosigine® to our Pre-Workout powder. Nitrosigine® is beneficial for those who want to get more out of their workout, and it is generally deemed safe for healthy individuals when taken properly. But you should always talk to your doctor before taking any supplements, as it could interact with blood thinners or other meds or supplements that you’re taking.

So if you’re looking to enhance your workout routine, try our Explosive Pre-Workout and see how Nitrosigine® can benefit you and your overall health.